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MOLOGEN Inc lefitolimod mgn 1703
Small-molecule agents under clinical development in immuno-oncology.
Lefitolimod Mgn 1703, supplied by MOLOGEN Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/mgn-1703/mgn1703/pmc10935485-33-1-5
Average 90 stars, based on 1 article reviews
lefitolimod mgn 1703 - by Bioz Stars, 2026-09
90/100 stars

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1) Product Images from "Small-molecule agents for cancer immunotherapy"

Article Title: Small-molecule agents for cancer immunotherapy

Journal: Acta Pharmaceutica Sinica. B

doi: 10.1016/j.apsb.2023.12.010

Small-molecule agents under clinical development in immuno-oncology.
Figure Legend Snippet: Small-molecule agents under clinical development in immuno-oncology.

Techniques Used:

Small-molecule agents in combinational therapies.
Figure Legend Snippet: Small-molecule agents in combinational therapies.

Techniques Used: Vaccines, Infection

Related Articles

Sandwich ELISA:

Article Title: Discontinued drugs in 2011: oncology drugs.
Article Snippet: sonline.com/Plan/ViewAbstract.aspx?sKey=1ee9fbdb-aspx?sKey=1ee9fbdb-

Article Title: Targeting Toll-like receptors: emerging therapeutics?
Article Snippet: DATABASES OMIM: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=OMIM actinic keratosis | inflammatory bowel disease UniProtKB: http://ca.expasy.org/sprot iNOS | MAL | MYD88 | SHIP-1 | TRAM | TRIF | ClinicalTrials.gov: http://clinicaltrials.gov/ NCT00729053 | NCT00633529 | NCT00719199 | NCT00251394 | NCT00403052 | NCT00091208 | NCT00675727 | NCT00728936 | NCT00990938 | NCT00823862 | NCT00603811 | NCT00688415 | NCT00770003 | NCT00999466 | NCT00547014 | NCT00334828 | NCT00633477 FURTHER INFORMATION Mologen Ag’s clinical development programe MgN‐1703: http://www.mologen.com/data/English/03_03_ Phase1.shtml Phase i clinical trial of Ave0675 in patients with allergy: http://en.sanofi-aventis.com/binaries/RD_2009-10-30_ Phase_I-II_EN_tcm28-24,004.pdf oPN‐401 development: http://www.opsona.com/index.jsp?p=117&n=121 Luke A. J. o’Neill’s homepage: http://www.tcd.ie/Biochemistry/research/l_o_neill.php

Article Title: Method of treating cancer in a patient by administering an antibody which binds colony stimulating factor-1 receptor (CSF-1R)
Article Snippet: In one embodiment of the invention the TLR9 agonist used in the combination treatment of the present invention is a oligodeoxynucleotides based CpG motif-containing circular ODN (e.g MGN-1703 from Mologen as described in WO2012/085291) based on the dSLIM® technology (this technology is described in WO2001/07055).

Article Title: Method of treating cancer by administering CSF-1R antibodies and a TLR9 agonist
Article Snippet: In one embodiment of the invention the TLR9 agonist of the invention is a oligodeoxynucleotides based CpG motif-containing circular ODN (e.g MGN-1703 from Mologen as described in WO2012/085291) based on the dSLIM® technology (this technology is described in WO2001/07055).

Article Title: Method for producing myeloid-derived suppressor cells, myeloid-derived suppressor cells produced thereby, and methods thereof
Article Snippet: In addition, in the present invention, the toll-like receptor 9 agonist may be, but is not limited to, an oligodeoxynucleotide based on CpG motif-containing circular ODN (for example, MGN-1703, manufactured by MOLOGEN AG, as described in WO 2012/085291), the CpG motif-containing circular ODN being produced based on the dSLIM (registered trademark) technology (which is described in WO 2001/07055).

Article Title: Method of treating cancer in a patient by administering an antibody which binds colony stimulating factor-1 receptor (CSF-1R)
Article Snippet: Several TLR9 agonist are known and currently developed in clinical testing Agatolimod (tricosasodium salt of a synthetic 24-mer oligonucleotide containing 3 CpG motifs; Pfizer) GNKGI68 (CpG ODN; SBI Biotech), IMO-2055 (synthetic oligonucleotide containing unmethylated CpG dinucleotides; Idera Pharmaceuticals), MGN-1703 (Mologen).

Isolation:

Article Title: Discontinued drugs in 2011: oncology drugs.
Article Snippet: sonline.com/Plan/ViewAbstract.aspx?sKey=1ee9fbdb-aspx?sKey=1ee9fbdb-

Article Title: Targeting Toll-like receptors: emerging therapeutics?
Article Snippet: DATABASES OMIM: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=OMIM actinic keratosis | inflammatory bowel disease UniProtKB: http://ca.expasy.org/sprot iNOS | MAL | MYD88 | SHIP-1 | TRAM | TRIF | ClinicalTrials.gov: http://clinicaltrials.gov/ NCT00729053 | NCT00633529 | NCT00719199 | NCT00251394 | NCT00403052 | NCT00091208 | NCT00675727 | NCT00728936 | NCT00990938 | NCT00823862 | NCT00603811 | NCT00688415 | NCT00770003 | NCT00999466 | NCT00547014 | NCT00334828 | NCT00633477 FURTHER INFORMATION Mologen Ag’s clinical development programe MgN‐1703: http://www.mologen.com/data/English/03_03_ Phase1.shtml Phase i clinical trial of Ave0675 in patients with allergy: http://en.sanofi-aventis.com/binaries/RD_2009-10-30_ Phase_I-II_EN_tcm28-24,004.pdf oPN‐401 development: http://www.opsona.com/index.jsp?p=117&n=121 Luke A. J. o’Neill’s homepage: http://www.tcd.ie/Biochemistry/research/l_o_neill.php

Article Title: Method of treating cancer in a patient by administering an antibody which binds colony stimulating factor-1 receptor (CSF-1R)
Article Snippet: In one embodiment of the invention the TLR9 agonist used in the combination treatment of the present invention is a oligodeoxynucleotides based CpG motif-containing circular ODN (e.g MGN-1703 from Mologen as described in WO2012/085291) based on the dSLIM® technology (this technology is described in WO2001/07055).

Article Title: Method of treating cancer by administering CSF-1R antibodies and a TLR9 agonist
Article Snippet: In one embodiment of the invention the TLR9 agonist of the invention is a oligodeoxynucleotides based CpG motif-containing circular ODN (e.g MGN-1703 from Mologen as described in WO2012/085291) based on the dSLIM® technology (this technology is described in WO2001/07055).

Article Title: Method for producing myeloid-derived suppressor cells, myeloid-derived suppressor cells produced thereby, and methods thereof
Article Snippet: In addition, in the present invention, the toll-like receptor 9 agonist may be, but is not limited to, an oligodeoxynucleotide based on CpG motif-containing circular ODN (for example, MGN-1703, manufactured by MOLOGEN AG, as described in WO 2012/085291), the CpG motif-containing circular ODN being produced based on the dSLIM (registered trademark) technology (which is described in WO 2001/07055).

Article Title: Method of treating cancer in a patient by administering an antibody which binds colony stimulating factor-1 receptor (CSF-1R)
Article Snippet: Several TLR9 agonist are known and currently developed in clinical testing Agatolimod (tricosasodium salt of a synthetic 24-mer oligonucleotide containing 3 CpG motifs; Pfizer) GNKGI68 (CpG ODN; SBI Biotech), IMO-2055 (synthetic oligonucleotide containing unmethylated CpG dinucleotides; Idera Pharmaceuticals), MGN-1703 (Mologen).

Gradient Centrifugation:

Article Title: Discontinued drugs in 2011: oncology drugs.
Article Snippet: sonline.com/Plan/ViewAbstract.aspx?sKey=1ee9fbdb-aspx?sKey=1ee9fbdb-

Article Title: Targeting Toll-like receptors: emerging therapeutics?
Article Snippet: DATABASES OMIM: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=OMIM actinic keratosis | inflammatory bowel disease UniProtKB: http://ca.expasy.org/sprot iNOS | MAL | MYD88 | SHIP-1 | TRAM | TRIF | ClinicalTrials.gov: http://clinicaltrials.gov/ NCT00729053 | NCT00633529 | NCT00719199 | NCT00251394 | NCT00403052 | NCT00091208 | NCT00675727 | NCT00728936 | NCT00990938 | NCT00823862 | NCT00603811 | NCT00688415 | NCT00770003 | NCT00999466 | NCT00547014 | NCT00334828 | NCT00633477 FURTHER INFORMATION Mologen Ag’s clinical development programe MgN‐1703: http://www.mologen.com/data/English/03_03_ Phase1.shtml Phase i clinical trial of Ave0675 in patients with allergy: http://en.sanofi-aventis.com/binaries/RD_2009-10-30_ Phase_I-II_EN_tcm28-24,004.pdf oPN‐401 development: http://www.opsona.com/index.jsp?p=117&n=121 Luke A. J. o’Neill’s homepage: http://www.tcd.ie/Biochemistry/research/l_o_neill.php

Article Title: Method of treating cancer in a patient by administering an antibody which binds colony stimulating factor-1 receptor (CSF-1R)
Article Snippet: In one embodiment of the invention the TLR9 agonist used in the combination treatment of the present invention is a oligodeoxynucleotides based CpG motif-containing circular ODN (e.g MGN-1703 from Mologen as described in WO2012/085291) based on the dSLIM® technology (this technology is described in WO2001/07055).

Article Title: Method of treating cancer by administering CSF-1R antibodies and a TLR9 agonist
Article Snippet: In one embodiment of the invention the TLR9 agonist of the invention is a oligodeoxynucleotides based CpG motif-containing circular ODN (e.g MGN-1703 from Mologen as described in WO2012/085291) based on the dSLIM® technology (this technology is described in WO2001/07055).

Article Title: Method for producing myeloid-derived suppressor cells, myeloid-derived suppressor cells produced thereby, and methods thereof
Article Snippet: In addition, in the present invention, the toll-like receptor 9 agonist may be, but is not limited to, an oligodeoxynucleotide based on CpG motif-containing circular ODN (for example, MGN-1703, manufactured by MOLOGEN AG, as described in WO 2012/085291), the CpG motif-containing circular ODN being produced based on the dSLIM (registered trademark) technology (which is described in WO 2001/07055).

Article Title: Method of treating cancer in a patient by administering an antibody which binds colony stimulating factor-1 receptor (CSF-1R)
Article Snippet: Several TLR9 agonist are known and currently developed in clinical testing Agatolimod (tricosasodium salt of a synthetic 24-mer oligonucleotide containing 3 CpG motifs; Pfizer) GNKGI68 (CpG ODN; SBI Biotech), IMO-2055 (synthetic oligonucleotide containing unmethylated CpG dinucleotides; Idera Pharmaceuticals), MGN-1703 (Mologen).



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Image Search Results


Small-molecule agents under clinical development in immuno-oncology.

Journal: Acta Pharmaceutica Sinica. B

Article Title: Small-molecule agents for cancer immunotherapy

doi: 10.1016/j.apsb.2023.12.010

Figure Lengend Snippet: Small-molecule agents under clinical development in immuno-oncology.

Article Snippet: , Lefitolimod (MGN 1703) , Mologen , TLR9 agonist , Phase II , NCT02200081.

Techniques:

Small-molecule agents in combinational therapies.

Journal: Acta Pharmaceutica Sinica. B

Article Title: Small-molecule agents for cancer immunotherapy

doi: 10.1016/j.apsb.2023.12.010

Figure Lengend Snippet: Small-molecule agents in combinational therapies.

Article Snippet: , Lefitolimod (MGN 1703) , Mologen , TLR9 agonist , Phase II , NCT02200081.

Techniques: Vaccines, Infection